Preimplantation Genetic Testing for Structural Rearrangements (PGT-SR or PGD)

What is PGT-SR?

PGT-SR is intended individuals who have a chromosomal rearrangement; a condition that causes a change in the size or arrangement of chromosomes. These individuals are at an increased risk of producing embryos with the incorrect amount of genetic material, that have a decreased chance of resulting in a healthy pregnancy. The PGT-SR test, which can be done in conjunction with your IVF cycle, can identify the amount of genetic material present in each embryo, so that only the embryos with the correct amount of genetic material can be chosen for transfer.

Who is it for?

PGT-SR is useful for individuals who have a chromosomal rearrangement. You may consider PGT-SR if you have had a child with a structural rearrangement, or if you or your partner are carriers of any of the following types of chromosomal rearrangements:

  • Reciprocal translocation
  • Robertsonian translocation
  • Balanced translocation
  • Unbalanced translocation
  • Inversion

How Does it Work?

Appointments & Information

Family Case is Reviewed

Your doctor will review your specific case and identify if PGT-SR is right for you. CReATe counselors are also available to help you understand the emotional implications of the test so you can make an informed decision.



PGT-SR is done in conjunction with your IVF cycle. On day 5 of embryo culture, the embryo has grown to about 100 cells. Half of these cells will create the baby and half will create the placenta.

IVF Embryo Process


To perform PGT-SR, a few cells from each embryo are biopsied from the part of the embryo that will form the placenta. The cells that will form the baby are untouched and unharmed. If you are also doing PGT-A testing, the same cells can provide information for both tests and no additional biopsy is needed.

DNA Testing


The removed cells are tested by our in-house geneticists to identify embryos affected by chromosomal rearrangements.

Embryo Transfer

Embryo Transfer

Embryos with the correct amount of genetic material will be selected for transfer into the uterus.

Can PGT-SR and PGT-A be done at the same time?

Yes, we can perform both tests at the same time. The same genetic material can be used to screen both the chromosomal health of the embryo (PGT-A) and to determine chromosomal rearrangements (PGT-SR).

How Long Does it Take?

We provide the fastest results for all genetic testing with PGT-SR results available in as little as 3-5 weeks post biopsy.