Recent publications

Clinical research

Gat I, Mejia SB, Balakier H, Librach CL, Claessens A, Ryan E. The use of Coenzyme Q10 and DHEA during IUI and IVF cycles in patients with decreased ovarian reserve. Gynecological Endocrinology. 2016 Feb 1 (In Press).

Zhoni K, Gat I, Librach C. Recurrent implantation failure: a comprehensive review. Minerva Ginecologica. 2016 December; 68(6): 653-67.

Chaikof M, Gat I, Lazer T, Quach K, Al Kudmani B, Zhoni K, Glass K, Sharma P, Baratz A, Librach C. Lower complication rates with office-based D&C under ultrasound guidance for missed abortions. Minerva Ginecologica. 2016 Jun.

Gat I, Shlush E, Quach K, Librach C. The Continuum of High Ovarian Response: Is it the Time to Differentiate between Sub-Populations and to Adopt Selected Treatments? Systems Biology in Reproductive Medicine. Epub 2015 Oct 30.

Lazer T, Dar S, Shlush E, Al Kudmani B, Quach K, Sharma P, Baratz A, Glass K, Librach C. Comparison of IVF Outcomes between Minimal Stimulation and High-Dose Stimulation for Patients with Poor Ovarian Reserve. International Journal of Reproductive Medicine. 2014 Oct 2;2014:2-7. Available from:

Dar S, Librach CL, Gunby J, Bissonnette F, and Cowan L. Increased risk for preterm birth in singleton pregnancies after blastocyst vs. day 3 embryo transfer – Canadian ART Register (CARTR) analysis. Human Reproduction. 2013 Apr 1;28(4):924-928.

Dar S, Lazer T, Shah P, Librach C. Neonatal outcomes among singleton births after blastocyst versus cleavage stage embryo transfer: A systematic review and meta-analysis. Human Reproduction Update. 2013;20(3):439-448.

Kimberley A Hill, Tova Nadler, Mandel R, Burlein-Hall, Librach C, Glass K, Warner E. Experience of Young Women Diagnosed with Breast Cancer Who Undergo Fertility Preservation Consultation. Clinical Breast Cancer. 2012;42:127-132.

Gunby J, Bissonnette F, Librach C, and Cowan L. Assisted reproductive technologies (ART) in Canada: 2007 results from the Canadian ART Register. Fertility and Sterility. 2010;95(2):542-7.e1-10. Epub 2010.

Stephenson M, Kutteh W, Purkiss S, Librach C, Houlihan E, Schultz P. Intravenous immunoglobulin (IVIG) for treatment of idiopathic secondary recurrent miscarriage (ISRM): a prospective, randomized, double-blinded, placebo-controlled, multi-centered trial. Fertility and Sterility. 2009;92(3):67-68.

Joanne Gunby, Francxois Bissonnette, Clifford Librach and Lisa Cowan. Assisted reproductive technologies in Canada: 2005 results from the Canadian Assisted Reproductive Technologies Register. Fertility and Sterility. 2008 Apr. epub.

Kotsopoulos J, Librach CL, Lubinski J, Gronwald J, Kim-Sing C, Ghadirian P, Lynch HT, Moller P, Foulkes WD, Randall S, Manoukian S, Pasini B, Tung N, Ainsworth S, Cummings S, Sun P, Narod SA, and the Hereditary Breast Cancer Clinical Study Group. Infertility, treatment of infertility, and the risk of breast cancer among women with BRCA1 and BRCA2 mutations: a case–control study. Cancer Causes Control. 2008;19:1111–1119.

Laredo, C.S.Rodgers, S. Ross, V. Speers, C. Mehling, D. McKay, A. Willan, D. Feig, R. Casper, L. Leiter, C. Librach, and M. Hannah. Effect of exercise in women with polycystic ovary syndrome (pcos): A randomized controlled trial of diet and exercise compared with diet alone. J Clin Endo Metab. 2008.

T.Tulandi, J.Martin, R. Al-Fadhli, N. Kabli, R. Forman, J. Hitkari, C. Librach, E. Greenblatt, and R. Casper. Congenital malformations among 911 newborns conceived after infertility treatment with letrozole or clomiphene citrate. Fertility and Sterility. 2006;85:1761-1765.

Joanne Gunby, François Bissonnette, Clifford Librach, and Lisa Cowan. Assisted reproductive technologies (ART) in Canada: 2004 results from the Canadian ART Register. Fertility and Sterility. 2007;89:1123-32.


Quach K, Grover S, Kenigsberg S, Librach C. A Combination of Single Nucleotide Polymorphisms in the 3’Untranslated Region of HLA-G is Associated with Preeclampsia. Human Immunology. 2014 Oct 9;75(12):1163-70.

Shang-mian Yie, Liang-hong Li, Rong Xiao, and Clifford L.Librach. A single base-pair mutation in the 3’-untranslated region of human leukocyte antigen G mRNA is associated with preeclampsia. Molecular Human Reproduction. 2008;14(11):649-653.

Shang-mian Yie, Rong Xiao, and Clifford L, Librach. Progesterone regulates HLA-G gene expression through a novel progesterone response element. Human Reproduction. 2006;21(10):2538-2544.

S Yie, L Li, G Li, R Xiao, and C L Librach. Progesterone Enhances Human Leukocyte Antigen G (HLA-G) Gene Expression In JEG-3 Choriocarcinoma Cell and Human Cytotrophoblasts In Vitro. Human Reproduction. 2006;21:46-51.

SM Yie, RT Taylor, and CL.Librach. Low plasma HLA-G protein concentrations in early gestation indicate the development of preeclampsia (PE) later in pregnancy. Am J Obstet Gynecol. 2005;193:204-8.


Balakier H, Sojeckie A, Motamedi G, and Librach C. Impact of multinucleated blastomeres on embryo developmental competence, morphokinetics, and aneuploidy. Fertility and Sterility. 2016 May 18. In Press.

Aarabi M, Balakier H, Bashar S, Moskovtsev S, Sutovsky P, Librach C, Oko R. Sperm-derived WW domain-binding protein, PAWP, elicits calcium oscillations and oocyte activation in humans and mice. FASEB. 2014 Oct 3;28(10):4434-4440. Co-Principal Author.

Aarabi M, Balakier H, Bashar S, Moskovtsev SI, Sutovsky P, Librach CL, Oko R. Sperm content of postacrosomal WW binding protein is related to fertilization outcomes in patients undergoing assisted reproductive technology. Fertility and Sterility. 2014 Aug;102(2):440-447. Available from: Co-Principal Author

Balakier H, Xiao R, Zhao J, Zaver S, Dziak E, Szczepanska K, Opas M, Yie S, Librach C. Expression of survivin in human oocytes and preimplantation embryos. Fertility and Sterility. 2013 Feb;99(2):518-525.

Balakier H, Sojecki A, Motamedi G, Siamak, Bashar, Mandel R, and Librach C. Is the zona pellucida thickness of human embryos influenced by women’s age, and hormonal levels? Fertility and Sterility. 2012;98(1):77-83.

Balakier H, Mandel R, Sojecki A, Motamedi G, Zaver S, Librach C. Laser zona thinning in women aged greater or equal to 37 years: a randomized study. Fertility and Sterility. 2009 Apr;91(1479-1482).

Shang-mian Yie, Hanna Balakier, Gelareh Motamedi, and Clifford L Librach. Secretion of human leukocyte antigen-G (HLA-G) by human embryos is associated with a higher IVF pregnancy rate. Fertility and Sterility. 2005;83(1):30-6.


Jodar M, Sendler E, Moskovtsev S, Librach C, Goodrich R, Swanson S, Hauser R, Diamond M, Krawetz S. Response to comment on “Absence of sperm RNA elements correlates with idiopathic male infertility”. Science Translational Medicine. 2016 Aug 24. Coauthor or Collaborator

Kuznyetsov V, Moskovtsev S, Crowe M, Lulat A, Librach CL. Vitrification of a small number of spermatozoa in normozoospermic and severely oligozoospermic samples. Systems Biology in Reproductive Medicine. 2014 Nov 21;61(1):13-17. Senior Responsible Author

Dar S, MD, Grover S, MSc, Moskovtsev SI, MD, PhD, Swanson S Msc, Baratz A MD and Librach CL, MD. IVF/ICSI outcome in Patients with a markedly high DNA fragmentation index (DFI>50%). Fertility and Sterility. 2013 Jul 1;100(1):75-80. Senior Responsible Author

Behrouzi B, Kenigsberg S, Alladin N, Swanson S, Zicherman J, Hong S, Moskovtsev S, Librach C. Evaluation of potential protein biomarkers in patients with high sperm DNA damage. Systems Biology in Reproductive Medicine. 2013 May 2;59(3):153-163. Principal Author

Moskovtsev SI, Librach CL. Methods of sperm vitality assessment. Methods in molecular biology, Research Gate. 2013;927:13-19. Senior Responsible Author

Firestone R, Esfandiari N, Moskovtsev SI, Burstein E, Videna GT, Librach C, Bentov Y, Casper RF. The Effects of Low-Level Laser Light Exposure on Sperm Motion Characteristics and DNA Damage. J Androl. 2012 Jul 14;33(3):469-473. Co-Principal Author

Alladin N, Moskovtsev SI, Russell H, Kenigsberg S, Lulat A, and Librach CL. Three-dimensional image analysis of the chromocentre in motile and immotile human sperm. Systems Biology in Reproductive Medicine. 2012 Jun 1;59(3):145-152. Senior Responsible Author

Moskovtsev S.I., Alladin N., Lo K.C., Jarvi K., Mullen J. B. M., and Librach C. L. A comparison of ejaculated and testicular spermatozoa aneuploidy rates in patients with high sperm DNA damage. Systems Biology in Reproductive Medicine. 2012;58(3):142-148. Senior Responsible Author

Ovarian Biology

Adams J, Liu Z, Ren YA, Wun WS, Zhou W, Kenigsberg S, Librach C, Valdes C, Gibbons W, Richards J. Enhanced Inflammatory Transcriptome in the Granulosa Cells of Women with Polycystic Ovarian Syndrome. Journal of Clinical Endocrinology & Metabolism. 2016 May 26. In Press. Coauthor or Collaborator.


Verlinsky Y, Rechitsky S, Laziuk K, Librach C, Genovese R, and Kuliev A. Preimplantation genetic diagnosis for Perlizaeus-Merzbacher disease with testing for age-related aneuploidies. Reprod Biomed Online. 2006;12:83-8.

Stem Cell Biology

Szaraz P, Iqbal F, Librach M, Maghen L, Barretto T, Kenigsberg S, Gauthier-Fisher A, Librach CL. In vitro differentiation of first trimester human umbilical cord perivascular cells into contracting cardiomyocyte-like cells. Stem Cell International. 2016 Mar 30

Librach M, Pereira S, Maghen L, Iqbal F, Barretto T, Park K, Szaraz P, Gauthier-Fisher A, Librach C. Optimization of xeno-free expansion conditions for human umbilical cord-derived perivascular cells using functional immunophenotyping and in vitro assays. Cytotherapy: The journal of cell therapy. 2015 Jun; 17(6) s82-83.

Hong SH, Maghen L, Kenigsberg S, Teichert A, Rameloo A, Shlush K, Szaraz P, Pereira S, Lulat A, Xiao R, Yie S, Gauthier-Fisher A, Librach C. Ontogeny of Human Umbilical Cord Perivascular Cells: Molecular and Fate Potential Changes During Gestation. Stem Cells and Development. 2013 Sep 1;22(17):2425-2439.

Psychosocial studies

Dar S, Lazer T, Swanson S, Silverman J, Wasser C, Moskovtsev S, Sojecki A, and Librach CL. Assisted reproduction involving Gestational Surrogacy: an analysis of the medical, psychosocial and legal issues. Experience from a large surrogacy program. Human Reproduction Update. 2014 Nov 25;30(2):345-352.

Grover S, Shmorgun Z, Moskovtsev SI, Baratz A, Librach CL. Assisted reproduction in a cohort of same-sex male couples and single men. Reproductive Biomedicine Online. 2013 Aug 1;27(2):217-221. Zhang Y, Margolese S, Yudin M, Raboud J, Diong C, Hart T, Muchenje M, Librach C, Gysler M, and Loutfy M. Desires, need, perceptions, and knowledge of assisted reproductive technologies in HIV-positive women of reproductive age in Ontario, Canada. ISRN Obstetrics and Gynecology. Epub 2012.

Quach S , Librach C. Infertility Knowledge and Attitudes in Urban High School Students. Fertility and Sterility. 2008 Dec;90(6):2099-106.