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Ovulation
induction involves the controlled administration of fertility drugs
that stimulate the ovary to produce a regular ovulation or multiple
eggs, depending on the circumstances. Ultrasound scans and blood
tests are usually undertaken cycle
monitoring to ensure that 1) you are responding to the medications
and 2) to time either intercourse or artificial insemination.
There
are various drug protocols that are commonly used. The first two
of these are given in a tablet form, and are called Clomiphene citrate
(Clomid or Serophene) or Letrozole (Femara). Clomiphene and Letrozole
work by stimulating your pituitary gland to release more follicle
stimulating hormone (FSH), which is the hormone required in the
latter stages of egg development. Normally this is given in a short
course at the beginning of the menstrual cycle for 5 days. Often
an additional hormone injection - human chorionic gonadotrophin
(hCG) is given when the follicle is mature to ensure that the egg(s)
is/are released from the follicle(s).
The
second type of fertility drug that is used is the hormone injection
known as a gonadotrophin (these contain a purified form of the hormone
FSH and possibly some LH hormone). There are a variety of gonadotrophin
preparations available (some common proprietary names include Gonal-F,
Puregon, Fertinex or Pergonal). Gonadotrophin injections are given
on a daily basis to try and stimulate the development of mature
follicle(s), which is/are then usually primed to release the egg
using an hCG injection when the follicle has reached an appropriate
size.
The
success of this type of treatment depends on many factors, such
as age, sperm counts, presence of endometriosis etc. Each cycle
a couple undergoes will have a certain probability of resulting
in a conception. It often takes a number of months of ovulation
induction treatment to conceive. If conception does not occur with
this method, your doctor may recommend other methods.
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